Breast cancer patients under 45 years of age using tissue microarray technique Role of immunohistochemical biomarkers
Breast cancer patients under 45 years of age using tissue microarray technique Role of immunohistochemical biomarkers Purpose: Tissue microarray (TMA) is used for the paraffin block of tumor tissue in patients under 45 years of age. Expression status of five biomarkers such as estrogen receptor (ER), progesterone receptor (PR), HER-2, COX-2 and Survivin And to investigate the significance as a prognostic factor in patients. Materials and Methods: From March 1994 to August 2005, TMA analysis was performed among breast cancer patients under 45 years of age A total of 212 patients were enrolled. The age of the patients ranged from 23 to 45 years and the median age was 39 years. The probing period was 24 months and the median follow - up period was 60 months. After selecting a patient under 45 years of age, After marking the cancerous area through the dyed slides, a microstructure array was made through a TMA instrument. And five living bodies Immunohistochemical staining of...